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Wolfe is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon. Magnetic resonance imaging and magnetic resonance angiogram of the brain, carotid and intracranial vessels were normal. Molecular biology techniques demonstrated several gene mutations, usually missense mutations, often involving exon 8 of the FVII gene.

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Blood-clotting mechanism has been analyzed by a procedure which devotes a separate experimental step to each of the three primary reactions: Oral administration of diphacinone over a range of doses sublethal to the extrapolated LD15 prolonged prothrombin time and Russell's Viper venom time within 24 to 48 hrs post-exposure.

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Knockdown of prothrombin in zebrafish. Thrombin is a serine protease generated from its zymogen, prothrombin , and plays a central role in the coagulation cascade. It is also important for mammalian development. The zebrafish has now been established as an excellent genetic model for studies on mammalian hemostasis and development.

In this report, we used prothrombin -specific antisense morpholinos to knock down the levels of prothrombin to characterize the effects of prothrombin deficiency in the zebrafish embryo.

Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding. In a second late phenotype, the embryos had no observable morphological abnormalities in early stages, but showed occasional bleeding at later stages.

These phenotypes resembled characteristics shown by prothrombin knockout mice. Laser-induced vascular injury on some of the normal appearing phenotypic larvae showed a prolonged time to occlusion, and recombinant zebrafish prothrombin injected into these larvae restored a normal time to occlusion thus showing the specificity of the morpholino effect.

The system developed here should be useful for investigation of the role of thrombin in vertebrate development. Affected people also have Pulmonary embolus General Information

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Macumar ersatz homosexual relationship
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